This lecture will explore the advancements in patient-specific total and partial knee replacement, focusing on how personalized implants and surgical techniques improve outcomes. The discussion will also cover the indications of patient-specific knee replacement and the different types of prosthesis that can be used to treat canine stifle diseases. Attendees will gain insight into the acquisition and evaluation of 3D imaging and the design of custom cutting guides and tailored implant. The personal experience of the author will be reported.